A physician, natural historian, and professor at the University of Pennsylvania, Benjamin Smith Barton (1766-1815) was one of the central figures in Philadelphia's early national scientific establishment. Having received his medical training in European universities, Barton was appointed Professor at the University of Pennsylvania in 1789, lecturing on botany, materia medica, natural history. A prolific author, he established his reputation as one of the nation's preeminent botanists through his botanical text book The Elements of Botany (1803), but his contribtions to zoology, ethnology, and medicine were equally noteworthy. Barton's monograph on the "fascinating faculty" of the rattlesnake and his efforts in historical linguistics (New Views of the Origin of the Tribes and Nations of America, 1798) were widely read, and his Philadelphia Medical and Physical Journal (1804-1809) was one of the nation's first medical journals and an important outlet for natural historical research. The Barton Papers offer a comprehensive view of the professional work of Benjamin Smith Barton from the time of his return to the United States in 1789 until his death. The collection is divided into five series: Correspondence, Subject Files, Bound Volumes, Graphic Materials, and Printing Plates. The collection includes a particularly valuable series of botanical, medical, and natural historical drawings collected by Barton for research, reference, and publication. Among the many artists represented are William Bartram, Frederick Pursh, Pierre Turpin, and Benjamin Henry Latrobe.

For many years referred to as the "Franz Boas Collection of American Indian Linguistics," this collection consists of a large body of linguistic and ethnographic material gathered together by Boas and many of his colleagues and students primarily from the 1890s to the 1940s. It contains the bulk of Boas's own fieldwork material, with the main exception of most of his Inuit and earliest Northwest Coast fieldwork. It contains the majority of the work sponsored by American Council of Learned Societies Committee on Native American Languages, which was directed by Franz Boas, Edward Sapir, Alfred Kroeber, and other academic linguists from 1927-1937. The collection, however, also contains related kinds of fieldwork and derived secondary materials created outside the auspices of this Committee, both earlier and later. The first deposit of the material arrivied in 1945. Subsequently, additional related materials were donated and added, as noted in the listings. Additionally, the documentary materials produced by some of the early projects (1945 to circa 1955) of the APS Phillips Fund for Native American Research were added to this collection. The collection has grown to over 80 linear feet of material representing at least 166 languages and dialects from the United States, Canada, and Mexico. The formats range from field notes and ethnographic texts to slip files, vocabularies, lexica, and grammars, and dozens of linguists and Native consultants are represented.